منابع مشابه
The gut: beyond immunology.
The immune system is characterized by the ability to distinguish self from non-self. The intestinal immune system bears this latter property but, furthermore, it must discriminate among nutritious and beneficial substances from toxic or harmful ones. Considering that the gut has to be colonized by commensal bacteria participating in digestion as well as in the control of pathogen microorganisms...
متن کاملGut reaction
The image above shows immunofluorescence staining of a cross-section of small intestine from a mouse with a 'mosaic' pattern of expression of cell-surface MHC (major histocompatibility complex) class I molecules. The mosaic effect can be seen on the intestinal villi, which contain stretches of epithelial cells that express MHC class I (bright green) interrupted by equally long stretches of cell...
متن کاملImmunology of the gut and oral tolerance
The gastrointestinal tract has developed a unique immunological system because of its close proximity to the intestinal contents. The system has evolved in such a way that it does not respond to the presence of beneficial microbes, but retains the ability to react quickly to the presence of harmful organisms. The challenge faced by the mucosal immune system is to generate an immune response of ...
متن کاملThe immunology of gluten sensitivity: beyond the gut.
The terms gluten sensitivity and coeliac disease (also known as gluten-sensitive enteropathy) have thus far been used synonymously to refer to a disease process affecting thesmall bowel andcharacterisedbymalabsorption and gastrointestinal symptoms. Yet, gluten sensitivity can exist even in the absence of an enteropathy. The systemic nature of this disease, the overwhelming evidence of an immune...
متن کاملImmunology and Pathology Symposium: Immunity, Nutrition, Genomics, and Gut Microbiota
Direct fed microbials (DFMs) are used in animals and humans as dietary supplements to improve health. In recent years, increased scrutiny by the Food and Drug Administration, regarding the use of subtherapeutic levels of antibiotics in food animal production has stimulated new interest in DFMs. Currently, our understanding of the mechanism(s) of action of DFMS and the factors that influence the...
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ژورنال
عنوان ژورنال: Science
سال: 2007
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.318.5855.1351a